Spatial RNA-Seq analysis showed proof-of-concept study of burn wound microenvironment published in WRR

In collaboration with the Angela Gibson lab, an analysis led by Parth showed “the capability of spatial transcriptomics to detect spatial gene expression patterns in burn tissue. 

Specifically, we show that

(i) spatially variable expressed genes are distinct across different burn depth regions, which would not be identified with bulk RNA-sequencing,

(ii) transcriptionally distinct burn tissue regions are defined by gene signatures associated with diverse cell types and biological pathways, and

(iii) these spatial gene signatures are identified in a subset of previously published bulk samples, suggesting their potential application in large-scale and integrated studies.