THE QUESTION

Cancer is a heterogeneous disease that complicates its study and therefore treatment. Immunotherapy has revolutionized cancer treatment but many patients still are facing with little or no clinical benefit with the same treatment. Recent high-dimensional technologies have allowed us the ability to understand the tumor ecosystem and its impact on treatment response. We are motivated by the questions of how the tumor microenvironment changes upon cancer progression, before and after treatment, and if we can predict treatment responses based on blood immune cell signatures.

THE APPROACH

We follow where science takes us. Currently, we leverage computational biology approaches, using high-dimensional data from multi-omics genome-wide (genomics and epigenomics) and single-cell assays, data mining, and bioinformatics. We develop and employ computational biology methods to mine publicly available data and in-house generated data for the specific questions we ask. We validate what we found in human data using independent data cohort, in vitro and in vivo approaches.

Ultimately, our goal is to understand how tumor immune microenvironment changes toward finding immunotherapeutic biomarkers and targets.

Although our central questions focus on cancer, we are open to the collaborative environment in Madison to explore similar questions in other diseases.

Lab News

  • Josh became a dissertator, Parth and Zach joined the lab

    Josh passed the preliminary exam and became a dissertator working on ovarian and colorectal cancer projects. Congratulations! Parth will officially be a joint PhD student co-supervised by Christina Kendziorski for his BDS PhD projects. Zach …

  • Wisconsin Immunomodulatory Targeted Radionuclide Therapy (ITRT) Program pilot project awarded

    We are awarded to study the roles of neutrophils in immunomodulatory targeted radionuclide therapy from the Wisconsin ITRT Program Project Grant in Head and Neck cancer. We are excited to join the community of Multi-disciplinary …

  • Anqi Gao joins the lab for her PhD study

    Anqi Gao officially joined the lab after her summer rotation from the MSTP program. She finished her 3rd year at medical school and will join the CMP graduate program as a Ph.D. student.  Anqi will …

  • New students joining the lab this summer

    New faces joining the lab this summer Alicia Tee (UW CS student) joined as a 2022 Summer LASER undergraduate scholar, working on making R Shiny apps to visualize scRNA-Seq data. Rishil Mehta (UW MD student) …

  • Josh was awarded a CMP T32 fellowship

    Josh was selected to be an NIH Trainee in the Cellular and Molecular Training Program for the school year of  2022-2023! Congrats! Thanks to the support from the National Institute Of General Medical Sciences of …

  • More News