Single-cell map of burn wound using larval zebrafish model is published in Journal of Immunology!

Our work, led by Yiran and Parth, employed integrated bioinformatics analyses of 6,495 neutrophils and 12,623 macrophages from scRNA-Seq of larval zebrafishes in both no-wound and burn conditions across 3 timepoints and mapped zebrafish neutrophil and macrophage signatures to a large-scale published dataset of 785 whole blood transcriptomes and identified signatures of neutrophil and macrophage subset correlated with human burn severity.

Key points:

• Functional diverse myeloid subsets are examined in larval zebrafish with and without burn wounds.
• Higher level neutrophilmacrophage communication is examined in burn wound conditions.
• Zebrafish neutrophil subset signatures are associated with human burn severity.