Together with Paul Lambert’s lab, we identified the roles of K17 contribution in HNC immunotherapy and the immune landscape switch from “cold tumors” to “hot tumors” using scRNA-Seq. The work was led by Wei Wang in the Lambert lab in collaboration with others from UWCCC. Athena was the analyst of TCGA and scRNA-Seq data. Congrats!
Wang W, Lozar T, Golfinos AE, Lee D, Groski E, Ward-Shaw E, Hayes M, Kimple RJ, Hu R, Xu J, Keske A, Sondel PM, Fitzpatrick MB, Dinh HQ#, Lambert PF# (2022). Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion and Resistance to Immune-Checkpoint Blockade Clin Cancer Res 2022 May 27:OF1-OF16. doi: 10.1158/1078-0432.CCR-21-3039.