Cancer is a heterogeneous disease that complicates its study and therefore treatment. Immunotherapy has revolutionized cancer treatment but many patients still are facing with little or no clinical benefit with the same treatment. Recent high-dimensional technologies have allowed us the ability to understand the tumor ecosystem and its impact on treatment response. We are motivated by the questions of how the tumor microenvironment changes upon cancer progression, before and after treatment, and if we can predict treatment responses based on blood immune cell signatures.
We follow where science takes us. Currently, we leverage computational biology approaches, using high-dimensional data from multi-omics genome-wide (genomics and epigenomics) and single-cell assays, data mining, and bioinformatics. We develop and employ computational biology methods to mine publicly available data and in-house generated data for the specific questions we ask. We validate what we found in human data using independent data cohort, in vitro and in vivo approaches.
Ultimately, our goal is to understand how tumor immune microenvironment changes toward finding immunotherapeutic biomarkers and targets.
Although our central questions focus on cancer, we are open to the collaborative environment in Madison to explore similar questions in other diseases.
We are awarded to study the roles of neutrophils in immunomodulatory targeted radionuclide therapy from the Wisconsin ITRT Program Project Grant in Head and Neck cancer. We are excited to join the community of Multi-disciplinary …July 25, 2022
Anqi Gao officially joined the lab after her summer rotation from the MSTP program. She finished her 3rd year at medical school and will join the CMP graduate program as a Ph.D. student. Anqi will …July 12, 2022
New faces joining the lab this summer Alicia Tee (UW CS student) joined as a 2022 Summer LASER undergraduate scholar, working on making R Shiny apps to visualize scRNA-Seq data. Rishil Mehta (UW MD student) …June 30, 2022
Josh was selected to be an NIH Trainee in the Cellular and Molecular Training Program for the school year of 2022-2023! Congrats! Thanks to the support from the National Institute Of General Medical Sciences of …June 10, 2022
Our joint paper with the Lambert lab defining the role of K17 and immune landscapes of head and neck cancer immunotherapy published in Clinical Cancer Research
Together with Paul Lambert’s lab, we identified the roles of K17 contribution in HNC immunotherapy and the immune landscape switch from “cold tumors” to “hot tumors” using scRNA-Seq. The work was led by Wei Wang …May 27, 2022
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